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KMID : 0369820080380040249
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Jorunal of Korean Pharmaceutical Sciences
2008 Volume.38 No. 4 p.249 ~ p.254
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Improved Dissolution of Solid Dispersed Atorvastatin Using Spray-Dryer
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Lee Jun-Hee
Kim Dae-Sung
Kim Won
Park Jong-Hak
Ahn Sik-Il
Kim Yun-Tae
Rhee John-M
Khang Gil-Son
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Abstract
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Solid dispersions of poorly water-soluble drug, atorvastatin, were prepared with Eudragit L100 to improve the solubility by spray dryer. To investigate the correlation between physicochemical properties and dissolution rate of solid dispersions, the samples were characterized by scanning electron microscopy (SEM), differential scanning calorimeter (DSC) and fourier transform infrared spectroscopy (FT-IR). SEM and DSC were found that atorvastatin is amorphous in the Eudragit L100 solid dispersion. FT-IR was used to analyze the salt formation by interaction between atorvastatin and Eudragit L100. The dissolution rate of solid dispersed atorvastatin was markedly increased compared to drug powder in stimulated intestinal juice (pH 6.8). Thus, the solid dispersed atorvastatin using the spray drying method with Eudragit L100 may be effective for the bioavailability.
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KEYWORD
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Atorvastatin calcium, Solid dispersion, Dissolution
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